Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | KDR | P35968 | 7/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | TEK | Q02763 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838604 | 0.83 | EGFR (0.35) | EGFRKDRENPP1CYP1A2KMT2A | |
| SCHEMBL7837582 | 0.79 | EGFR (0.35) | EGFRKDRDRD1TRPA1 | |
| SCHEMBL8816236 | 0.78 | EGFR (0.57) | EGFRKDRKMT2ARETKIF5B | |
| SCHEMBL8814662 | 0.76 | EGFR (0.42) | EGFRKMT2ALMNA | |
| SCHEMBL7822489 | 0.74 | LMNA (0.41) | EGFRKDRKDM1ADRD1MAPK7 | |
| SCHEMBL7840014 | 0.72 | PDPK1 (0.43) | METLMNARAB9ARAF1BRAF | |
| SCHEMBL7350494 | 0.72 | ALDH1A1 (0.37) | CYP1A2KMT2ALMNARAB9A | |
| SCHEMBL22407632 | 0.71 | CSF1R (0.41) | EGFRKDRAURKBENPP1CSF1R | |
| SCHEMBL22407633 | 0.70 | CA1 (0.49) | EGFRKDRAURKBENPP1CSF1R | |
| SCHEMBL25682912 | 0.69 | CSF1R (0.39) | EGFRKDRAURKBENPP1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802914-B1 | ARYL- AND HETEROARYL- PURINE AND PYRIDOPYRIMIDINE DERIVATIVES | PHARMACIA & UPJOHN SPA (IT) | 2001-06-06 | — | — | EP | claimed |