Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.93 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.93 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.93 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.93 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.51 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | GABRP | O00591 | 1/20 | 0.51 |
| ▸ | GABRD | O14764 | 1/20 | 0.51 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.51 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.51 |
| ▸ | GABRE | P78334 | 1/20 | 0.51 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.51 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10866374 | 0.80 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10749256 | 0.75 | GABRA1 (0.78) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1760407 | 0.75 | ALOX5 (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9647920 | 0.74 | ALOX5 (0.57) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10484805 | 0.70 | GAA (0.65) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL26646796 | 0.70 | ALOX5 (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL720666 | 0.70 | POLB (0.66) | — | |
| SCHEMBL17236324 | 0.68 | HDAC6 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL3646887 | 0.68 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL29692654 | 0.68 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4312870-A | TRANQUILIZERS, ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1982-01-26 | — | — | US | claimed |
| WO-1991006298-A1 | NEW USE OF CONDENSED QUINOLINE COMPOUND | KABI PHARMACIA THERAPEUTICS AB (SE) | 1991-05-16 | — | — | WO | disclosed |
| US-4758427-A | Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone | CIBA-GEIGY CORPORATION (US) | 1988-07-19 | — | — | US | disclosed |
| EP-0214092-A1 | Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone | CIBA-GEIGY AG (CH) | 1987-03-11 | — | — | EP | disclosed |
| US-4595684-A | Method of suppressing benzodiazepine induced sedation with 2-(p-methoxypenyl)-pyrazolo[4,3-c]quinolin-3(5H)-one or a salt thereof | CIBA-GEIGY CORPORATION (US) | 1986-06-17 | — | — | US | disclosed |
| EP-0022078-B1 | PYRAZOLO-QUINOLINES, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CIBA-GEIGY AG (CH) | 1984-07-25 | — | — | EP | disclosed |
| US-4312870-A | TRANQUILIZERS, ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1982-01-26 | — | — | US | disclosed |
| US-4312870-A | TRANQUILIZERS, ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1982-01-26 | — | — | US | disclosed |
| EP-0022078-A1 | Pyrazolo-quinolines, processes for their production, and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1981-01-07 | — | — | EP | disclosed |