Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CTSV | O60911 | 5/20 | 0.51 |
| ▸ | CTSL | P07711 | 5/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350886 | 1.00 | MEN1 (0.54) | MEN1KMT2AMAPTCTSVCTSL | |
| SCHEMBL7350875 | 0.95 | MEN1 (0.56) | MEN1KMT2AMAPTCTSVCTSL | |
| SCHEMBL27551196 | 0.83 | MEN1 (0.55) | MEN1KMT2AMAPTCTSVCTSL | |
| SCHEMBL5421861 | 0.83 | POLB (0.58) | MEN1KMT2AMAPTCTSVCTSL | |
| SCHEMBL29502844 | 0.83 | POLB (0.58) | MEN1KMT2AMAPTCTSVCTSL | |
| SCHEMBL5501006 | 0.82 | MEN1 (0.59) | MEN1KMT2AMAPTCTSVCTSL | |
| SCHEMBL7682013 | 0.81 | MAPT (0.52) | MEN1KMT2AMAPTPOLBNPC1 | |
| SCHEMBL7682016 | 0.81 | MAPT (0.52) | MEN1KMT2AMAPTPOLBNPC1 | |
| SCHEMBL8875982 | 0.81 | RAB9A (0.55) | MEN1KMT2AMAPTCTSVCTSL | |
| SCHEMBL3997761 | 0.80 | MEN1 (0.67) | MEN1KMT2AMAPTCTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027332-A1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999018074-A1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | Britol-Myers Squibb Pharma Company (US) | 1999-04-15 | — | — | WO | disclosed |