Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7682016 | 1.00 | MAPT (0.52) | MAPTTHRBAKR1C3AKR1C2NPC1 | |
| SCHEMBL7682008 | 0.93 | MAPT (0.55) | MAPTTHRBAKR1C3AKR1C2NPC1 | |
| SCHEMBL9652442 | 0.89 | SMN1; SMN2 (0.48) | MAPTAKR1C3AKR1C2NPC1RAB9A | |
| SCHEMBL12704884 | 0.86 | MAPT (0.51) | MAPTTHRBAKR1C3AKR1C2NPC1 | |
| SCHEMBL12993689 | 0.81 | MAPT (0.54) | MAPTTHRBAKR1C3AKR1C2NPC1 | |
| SCHEMBL7350886 | 0.81 | MEN1 (0.54) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL7350879 | 0.81 | MEN1 (0.54) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2729880 | 0.81 | ALDH1A1 (0.45) | MAPTAKR1C3AKR1C2NPC1RAB9A | |
| SCHEMBL7683703 | 0.81 | ALDH1A1 (0.49) | MAPTNPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL2698893 | 0.81 | MEN1 (0.61) | MAPTAKR1C3AKR1C2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6469181-B1 | PREPARING 2-OXINDOLES AND N-HYROXY-2- OXINDOLES VIA REDUCTION OF 2-NITROARYLMALONATE DIESTERS WITHOUT ISOLATION OF INTERMEDIATES | CATALYTICA, INC. | 2002-10-22 | — | — | US | disclosed |