Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 10/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 10/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 10/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.58 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | ECE1 | P42892 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355336 | 1.00 | GABRG2 (0.58) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7355224 | 0.88 | GABRA1 (0.56) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7359714 | 0.80 | GABRG2 (0.67) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7355146 | 0.78 | GABRG2 (0.70) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7359238 | 0.78 | GABRA1 (0.56) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7354407 | 0.76 | GABRA1 (0.54) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7354537 | 0.76 | GABRG2 (0.54) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7355615 | 0.76 | GABRG2 (0.78) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7354063 | 0.75 | KDM4E (0.40) | STAT3BRD4 | |
| SCHEMBL7354058 | 0.75 | KDM4E (0.40) | STAT3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156761-A | Substituted tetralone derivatives for enhancing cognition | MERCK SHARPE & DOHME LIMITED (GB) | 2000-12-05 | — | — | US | disclosed |