Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354058 | 1.00 | KDM4E (0.40) | KDM4ECYP1A2BRD4ALDH1A1PKM | |
| SCHEMBL7359720 | 0.80 | KDM4E (0.62) | KDM4ECYP1A2BRD4ALDH1A1ACHE | |
| SCHEMBL7349576 | 0.76 | KDM4E (0.40) | KDM4EBRD4ALDH1A1 | |
| SCHEMBL7355336 | 0.75 | GABRG2 (0.58) | BRD4STAT3 | |
| SCHEMBL7350948 | 0.75 | GABRG2 (0.58) | BRD4STAT3 | |
| SCHEMBL7351763 | 0.74 | STAT3 (0.44) | KDM4ECYP1A2BRD4ALDH1A1STAT3 | |
| SCHEMBL7349414 | 0.72 | GABRG2 (0.39) | KDM4ECYP1A2STAT3 | |
| SCHEMBL7357100 | 0.68 | KDM4E (0.35) | KDM4EBRD4ALDH1A1PKMSTAT3 | |
| SCHEMBL10982867 | 0.67 | ACHE (0.62) | KDM4EBRD4ALDH1A1ACHE | |
| SCHEMBL7361535 | 0.66 | GABRG2 (0.58) | KDM4EBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156761-A | Substituted tetralone derivatives for enhancing cognition | MERCK SHARPE & DOHME LIMITED (GB) | 2000-12-05 | — | — | US | disclosed |