SCHEMBL7351108

SCHEMBL7351108

N[C@@H](CCc1ccccc1)C(=O)[C]=Cc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.47
ANPEP P15144 1/20 0.47
ERAP2 Q6P179 1/20 0.47
ERAP1 Q9NZ08 1/20 0.47
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
TAAR1 Q96RJ0 1/20 0.43
KMT2A Q03164 5/20 0.43
MEN1 O00255 4/20 0.43
GRIK1 P39086 1/20 0.42
GRIK2 Q13002 1/20 0.42
BRAF P15056 1/20 0.41
MMP2 P08253 1/20 0.41
ALDH1A1 P00352 2/20 0.41
BCHE P06276 1/20 0.40
MAOB P27338 1/20 0.40
CRHBP P24387 1/20 0.40
CRHR2 Q13324 1/20 0.40
GRM8 O00222 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8366516 0.83 MMP2 (0.48) MAPTANPEPERAP2ERAP1NPC1
SCHEMBL7354760 0.76 CTSK (0.53) MAPTKMT2AMEN1
SCHEMBL8092467 0.75 GRM8 (0.56) ANPEPERAP2ERAP1KMT2AMEN1
SCHEMBL7358695 0.75 GRM8 (0.56) ANPEPERAP2ERAP1KMT2AMEN1
SCHEMBL6076979 0.74 RAB9A (0.53) MAPTANPEPERAP2ERAP1NPC1
SCHEMBL12620878 0.74 MEN1 (0.58) MAPTANPEPERAP2ERAP1NPC1
SCHEMBL6076971 0.74 RAB9A (0.53) MAPTANPEPERAP2ERAP1NPC1
SCHEMBL7413122 0.74 MAPT (0.52) MAPTANPEPERAP2ERAP1NPC1
SCHEMBL7413123 0.74 MAPT (0.52) MAPTANPEPERAP2ERAP1NPC1
SCHEMBL7413125 0.74 MAPT (0.52) MAPTANPEPERAP2ERAP1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6287840-B1 PEPTIDOMIMETICS; COUPLING, DEBLOCKING; ANTIARTHRITIC, ANTITUMOR, ANTICARCINOGENIC, AND ANTIMETASTASIS AGENTS; MUSCULAR DYSTROPHY, GLOMERULONEPHRITIS, MALARIA, ALZHEIMER*S DISEASE AXYS PHARMACEUTICALS, INC. 2001-09-11 US disclosed
US-5976858-A (S)-(E)-3-(4-MORPHOLINE-CARBONYLLEUCYL)AMINO-5-PHENYL-1-PHENYL SULFONYL-1-PENTENE AND OTHERS; ANTIARTHRITIS/ANTITUMOR/ ANTIINFLAMMATORY/ANTIMETASTASIS AGENTS; TREATMENT OF MUSCULAR DYSTROPHY, MALARIA, ALZHEIMER'S AND AUTOIMMUNE DISEASES ARRIS PHARMACEUTICALS (US) 1999-11-02 US disclosed
EP-0756625-A4 IRREVERSIBLE CYSTEINE PROTEASE INHIBITORS CONTAINING VINYL GROUPS CONJUGATED TO ELECTRON WITHDRAWING GROUPS ARRIS PHARM CORP (US) 1999-07-28 EP disclosed
EP-0756625-A1 IRREVERSIBLE CYSTEINE PROTEASE INHIBITORS CONTAINING VINYL GROUPS CONJUGATED TO ELECTRON WITHDRAWING GROUPS ARRIS PHARMACEUTICAL CORPORATION (US) 1997-02-05 EP disclosed
WO-1995023222-A1 IRREVERSIBLE CYSTEINE PROTEASE INHIBITORS CONTAINING VINYL GROUPS CONJUGATED TO ELECTRON WITHDRAWING GROUPS KHEPRI PHARMACEUTICALS, INC. (US) 1995-08-31 WO disclosed