Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.49 |
| ▸ | CTSD | P07339 | 3/20 | 0.42 |
| ▸ | CTSE | P14091 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14415365 | 0.72 | REN (0.61) | RENCTSDCTSEALDH1A1 | |
| SCHEMBL7351443 | 0.72 | REN (0.64) | RENCTSDCTSE | |
| SCHEMBL9755311 | 0.66 | REN (0.67) | RENCTSDCTSE | |
| SCHEMBL9640485 | 0.65 | REN (0.54) | RENCTSDCTSE | |
| SCHEMBL10378904 | 0.64 | POLB (0.54) | RENCTSDCTSEALDH1A1 | |
| SCHEMBL10448076 | 0.63 | REN (0.54) | RENCTSDCTSEALDH1A1 | |
| SCHEMBL15532120 | 0.63 | REN (0.81) | RENCTSDCTSE | |
| Hydrochloric Acid SCHEMBL10431267 | 0.60 | CYP3A4 (0.58) | RENCTSDCTSEALDH1A1 | |
| SCHEMBL14415384 | 0.60 | REN (0.55) | RENCTSDCTSE | |
| SCHEMBL14420310 | 0.60 | REN (0.55) | RENCTSDCTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4894437-A | Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties | THE UPJOHN COMPANY (US) | 1990-01-16 | — | — | US | claimed |
| EP-0245361-A1 | NOVEL RENIN INHIBITING POLYPEPTIDE ANALOGS CONTAINING S-ARYL-D- OR L- OR DL-CYSTEINYL, 3-(ARYLTHIO)LACTIC ACID OR 3-(ARYLTHIO)ALKYL MOIETIES | THE UPJOHN COMPANY (US) | 1987-11-19 | — | — | EP | claimed |
| WO-1987002986-A1 | NOVEL RENIN INHIBITING POLYPEPTIDE ANALOGS CONTAINING S-ARYL-D- OR L- OR DL-CYSTEINYL, 3-(ARYLTHIO)LACTIC ACID OR 3-(ARYLTHIO)ALKYL MOIETIES | THE UPJOHN COMPANY (US) | 1987-05-21 | — | — | WO | claimed |