Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7344633 | 0.88 | SLC6A4 (0.36) | SLC6A4SLC7A5SLC6A2SLC6A3KCNH2 | |
| SCHEMBL7346888 | 0.84 | NPC1 (0.40) | SLC6A4SLC7A5SLC6A2SLC6A3KCNH2 | |
| SCHEMBL7353033 | 0.83 | SLC6A4 (0.36) | SLC6A4SLC7A5SLC6A2SLC6A3KCNH2 | |
| SCHEMBL7353677 | 0.83 | SLC6A4 (0.38) | SLC6A4SLC6A3LMNA | |
| SCHEMBL7352429 | 0.81 | POLB (0.32) | SLC6A4PKMAPLNR | |
| SCHEMBL7348352 | 0.81 | SLC6A4 (0.44) | SLC6A4SLC7A5SLC6A2SLC6A3KCNH2 | |
| SCHEMBL7347171 | 0.80 | SLC6A4 (0.42) | SLC6A4LMNA | |
| SCHEMBL7349866 | 0.80 | L3MBTL1 (0.41) | PKMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7354056 | 0.80 | SLC1A5 (0.38) | SLC6A4APLNRCYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7349930 | 0.80 | HTR1A (0.33) | SLC6A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972764-A1 | Aminoalcohols and aminoketones as CNS active agents | Universita Degli Studi di Firenze (IT) | 2000-01-19 | — | — | EP | claimed |
| EP-0972764-A1 | Aminoalcohols and aminoketones as CNS active agents | Universita Degli Studi di Firenze (IT) | 2000-01-19 | — | — | EP | disclosed |