Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.41 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.41 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.41 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | PRKACG | P22612 | 1/20 | 0.39 |
| ▸ | PRKACB | P22694 | 1/20 | 0.39 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349479 | 0.92 | PGR (0.42) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL7352859 | 0.90 | PARG (0.41) | PARGGRIK1GRIK2GRIK3GRIK4 | |
| SCHEMBL7354370 | 0.86 | SRC (0.46) | PARGGRIK1GRIK2GRIK3GRIK4 | |
| SCHEMBL7353155 | 0.82 | PARG (0.40) | PARGGRIK1GRIK2GRIK3GRIK4 | |
| SCHEMBL7354078 | 0.81 | SIRT2 (0.43) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL9395755 | 0.80 | PGR (0.54) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7358401 | 0.80 | GRIA1 (0.45) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL7352546 | 0.78 | PARG (0.47) | PARGSRCPRKACAPRKACGPRKACB | |
| SCHEMBL7353282 | 0.78 | SIRT2 (0.45) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL7352345 | 0.77 | CCR2 (0.46) | PARGGRIK1GRIK2GRIK3GRIK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993008173-A1 | QUINOXALINE DERIVATES WITH AFFINITY FOR QUISQUALATE-RECEPTORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-04-29 | — | — | WO | claimed |
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| US-6057304-A | Quinoxaline-phosphonic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |