Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.42 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.42 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.42 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354078 | 0.87 | SIRT2 (0.43) | SIRT2SIRT1GRIK1GRIK2GRIK3 | |
| SCHEMBL7361295 | 0.84 | SIRT2 (0.46) | SIRT2SIRT1GRIK1GRIK2GRIK3 | |
| SCHEMBL7358401 | 0.81 | GRIA1 (0.45) | SIRT2SIRT1GRIK1GRIK2GRIK3 | |
| SCHEMBL9542780 | 0.81 | SIRT2 (0.52) | SIRT2SIRT1GRIK1GRIK2GRIK3 | |
| SCHEMBL7354618 | 0.81 | SIRT2 (0.46) | SIRT2SIRT1GRIK1GRIK2GRIK3 | |
| SCHEMBL7353289 | 0.81 | GRIK1 (0.40) | SIRT2SIRT1GRIK1GRIK2GRIK3 | |
| SCHEMBL7353360 | 0.80 | GRIK1 (0.59) | SIRT2SIRT1GRIK1GRIK2GRIK3 | |
| SCHEMBL7357748 | 0.79 | SIRT2 (0.48) | SIRT2SIRT1GRIK1GRIK2GRIK3 | |
| SCHEMBL8609548 | 0.79 | CYP1A2 (0.57) | SIRT2SIRT1GRIA1GRIA2GRIA3 | |
| SCHEMBL7353149 | 0.78 | PARG (0.42) | SIRT2SIRT1GRIK1GRIK2GRIK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| US-6057304-A | Quinoxaline-phosphonic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |