Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 4/20 | 0.39 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CPT2 | P23786 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL673949 | 0.95 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL735448 | 0.95 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28282255 | 0.95 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28259791 | 0.95 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4094346 | 0.95 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL25332361 | 0.92 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL10561739 | 0.92 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL8647305 | 0.92 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1932644 | 0.92 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL25331832 | 0.92 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106633451-A | Preparation method for extruding polystyrene foaming material with CO2 composite foaming agent | 贵州五洲新材料科技有限公司 | 2017-05-10 | — | — | CN | disclosed |
| EP-1940316-A2 | PRESSURE ATTENUATION DEVICE | Solace Therapeutics, Inc. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007038476-A9 | PRESSURE ATTENUATION DEVICE | ATTENEUX TECHNOLOGIES INC (US) | 2008-04-03 | — | — | WO | disclosed |
| EP-1572285-A4 | IMPLANTABLE PRESSURE ATTENUATION DEVICE | SOLACE THERAPEUTICS INC (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2007038476-A2 | PRESSURE ATTENUATION DEVICE | ATTENEUX TECHNOLOGIES, INC. (US) | 2007-04-05 | — | — | WO | disclosed |
| EP-1572285-A2 | IMPLANTABLE PRESSURE ATTENUATION DEVICE | Solace Therapeutics, Inc. (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004030518-A2 | IMPLANTABLE PRESSURE ATTENUATION DEVICE | SOLACE THERAPEUTICS, INC. (US) | 2004-04-15 | — | — | WO | disclosed |
| US-5948399-A | Aqua ammonia production by desorption | MCGLOTHLIN MARK W (US) | 1999-09-07 | — | — | US | disclosed |
| EP-0837703-A4 | APPARATUS FOR CONTROLLED FLUID DELIVERY | RIVER MEDICAL INC (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0837703-A1 | APPARATUS FOR CONTROLLED FLUID DELIVERY | RIVER MEDICAL, INC. (US) | 1998-04-29 | — | — | EP | disclosed |
| US-5729956-A | DISSOLVING | APEX MEDICAL TECHNOLOGIES, INC (US) | 1998-03-24 | — | — | US | disclosed |
| WO-1997002849-A1 | APPARATUS FOR CONTROLLED FLUID DELIVERY | RIVER MEDICAL, INC. (US) | 1997-01-30 | — | — | WO | disclosed |
| EP-0748252-A1 | GAS DELIVERY APPARATUS AND COMPOSITIONS FOR INFUSION | RIVER MEDICAL, INC. (US) | 1996-12-18 | — | — | EP | disclosed |
| WO-1995023641-A1 | GAS DELIVERY APPARATUS AND COMPOSITIONS FOR INFUSION | RIVER MEDICAL, INC. (US) | 1995-09-08 | — | — | WO | disclosed |