Citric Acid

Citric Acid

SCHEMBL673949

O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])[O-].[Ca+2]

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.38
ALDH1A1 P00352 2/20 0.79
SLC13A5 Q86YT5 6/20 0.43
HMGCR P04035 1/20 0.42
CHRM1 P11229 1/20 0.42
TBXA2R P21731 1/20 0.42
ADRA1A P35348 1/20 0.42
TSHR P16473 2/20 0.40
CYP2D6 P10635 2/20 0.40
CYP2C19 P33261 1/20 0.40
HIF1A Q16665 1/20 0.40
KDM4E B2RXH2 2/20 0.40
LMNA P02545 2/20 0.40
MAPT P10636 1/20 0.40
ALOX15 P16050 1/20 0.40
ACLY P53396 3/20 0.39
CA4 P22748 1/20 0.39
CPT2 P23786 1/20 0.38
CYP1A2 P05177 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL27950719 0.97 ALDH1A1 (0.75) ALDH1A1SLC13A5HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL21372603 0.95 ALDH1A1 (0.79) ALDH1A1SLC13A5HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL28259791 0.95 ALDH1A1 (0.79) ALDH1A1SLC13A5HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL28282255 0.95 ALDH1A1 (0.79) ALDH1A1SLC13A5HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL4094346 0.95 ALDH1A1 (0.79) ALDH1A1SLC13A5HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL735448 0.95 ALDH1A1 (0.79) ALDH1A1SLC13A5HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL5030701 0.95 ALDH1A1 (0.79) ALDH1A1SLC13A5HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL25331832 0.92 ALDH1A1 (0.75) ALDH1A1SLC13A5HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL8647305 0.92 ALDH1A1 (0.75) ALDH1A1SLC13A5HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL10561739 0.92 ALDH1A1 (0.75) ALDH1A1SLC13A5HMGCRCHRM1TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110303558-A A kind of preparation method of the net aldehyde glued board of sound insulation 南京林业大学 2019-10-08 CN claimed
CN-107156223-A Nutrient biscuit and preparation method thereof after one kind is run 广州宏韵医药科技股份有限公司 2017-09-15 CN claimed
US-20170000922-A1 METHODS AND DRESSINGS FOR SEALING INTERNAL INJURIES STB, LTD. (US) 2017-01-05 US claimed
US-20160317700-A1 SOLID DRESSING FOR TREATING WOUNDED TISSUE STB, LTD. (US) 2016-11-03 US claimed
US-20160121016-A1 METHODS AND DRESSINGS FOR SEALING INTERNAL INJURIES STB, LTD. (US) 2016-05-05 US claimed
US-9259503-B2 Methods and dressings for sealing internal injuries STB, LTD. (US) 2016-02-16 US claimed
US-20160038347-A1 COMPOSITIONS HAVING CYLINDRICAL VOLUME, METHODS, AND APPLICATORS FOR SEALING INJURIES RESOURCE TRANSITION CONSULTANTS, LLC 2016-02-11 US claimed
US-20150352245-A1 METHODS AND DRESSINGS FOR SEALING INTERNAL INJURIES STB, LTD. (US) 2015-12-10 US claimed
US-20150283288-A1 SOLID DRESSING FOR TREATING WOUNDED TISSUE STB, LTD. (US) 2015-10-08 US claimed
US-9131929-B2 Methods and dressings for sealing internal injuries STB, LTD. (US) 2015-09-15 US claimed
EP-2059205-A2 PROCESSES FOR THE PRODUCTION OF SOLID DRESSING FOR TREATING WOUNDED TISSUE Stb Lifesaving Technologies, Inc. (US) 2009-05-20 EP claimed
US-20090075891-A1 Methods and dressings for sealing internal injuries STB, LTD 2009-03-19 US claimed
WO-2009020612-A1 METHODS AND DRESSING FOR SEALING INTERNAL INJURIES STB LIFESAVING TECHNOLOGIES, INC. (US) 2009-02-12 WO claimed
WO-2008019129-A2 SOLID DRESSING FOR TREATING WOUNDED TISSUE STB LIFESAVING TECHNOLOGIES, INC. (US) 2008-02-14 WO claimed
WO-2008019126-A2 PROCESS FOR PRODUCTION OF SOLID WOUND DRESSING STB LIFESAVING TECHNOLOGIES, INC. (US) 2008-02-14 WO claimed
WO-2008019127-A2 SOLID DRESSING FOR TREATING WOUNDED TISSUE STB LIFESAVING TECHNOLOGIES, INC. (US) 2008-02-14 WO claimed
US-20080031934-A1 Processes for the production of solid dressings for treating wounded tissue RESOURCE TRANSITION CONSULTANTS, LLC 2008-02-07 US claimed
US-20080033332-A1 Solid dressing for treating wounded tissue STB, LTD 2008-02-07 US claimed
US-20080033333-A1 Solid dressing for treating wounded tissue STB, LTD 2008-02-07 US claimed
US-20080033331-A1 Solid dressing for treating wounded tissue STB, LTD 2008-02-07 US claimed