Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.58 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | RNF4 | P78317 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8509514 | 0.93 | MMP8 (0.55) | MMP8NPY5RTSHRMMP2LMNA | |
| SCHEMBL8508382 | 0.93 | MMP8 (0.53) | MMP8NPY5RS1PR1LTA4HSMN1; SMN2 | |
| SCHEMBL8507827 | 0.87 | NPY5R (0.56) | MMP8NPY5RRECQL | |
| SCHEMBL8507779 | 0.85 | MMP8 (0.62) | MMP8HDAC1TSHRMMP2 | |
| SCHEMBL8508468 | 0.81 | SMN1; SMN2 (0.53) | MMP8NPY5RMMP2SMN1; SMN2LMNA | |
| SCHEMBL8507887 | 0.80 | MMP8 (0.47) | MMP8HDAC1SMN1; SMN2 | |
| SCHEMBL7354597 | 0.80 | NPY5R (0.56) | MMP8NPY5RS1PR1 | |
| SCHEMBL8509498 | 0.80 | MMP8 (0.55) | MMP8NPY5RTP53 | |
| SCHEMBL1373888 | 0.77 | LTA4H (0.62) | NPY5RHDAC1S1PR1LTA4H | |
| SCHEMBL1373889 | 0.77 | LTA4H (0.62) | NPY5RHDAC1S1PR1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009736-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | Roche Diagnostics GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| EP-0911319-A1 | Malonic acid based matrix metalloproteinase inhibitors | Roche Diagnostics GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |
| WO-1999011608-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-03-11 | — | — | WO | disclosed |