Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30657896 | 1.00 | PTGS1 (0.41) | PTGS1PTGS2MAPTCYP2C9POLB | |
| SCHEMBL10784087 | 0.83 | ALDH1A1 (0.48) | PTGS1PTGS2MAPTCYP2C9POLB | |
| SCHEMBL24105617 | 0.80 | L3MBTL1 (0.42) | CYP2C9POLBALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL30049391 | 0.80 | GAA (0.45) | PTGS1PTGS2MAPTCYP2C9POLB | |
| SCHEMBL17559533 | 0.78 | POLB (0.36) | PTGS1PTGS2MAPTPOLBALDH1A1 | |
| SCHEMBL8398705 | 0.77 | POLB (0.54) | PTGS1PTGS2MAPTCYP2C9POLB | |
| SCHEMBL28052138 | 0.76 | PTGS1 (0.39) | PTGS1PTGS2MAPTCYP2C9POLB | |
| SCHEMBL14812208 | 0.72 | HPGD (0.48) | PTGS1PTGS2MAPTCYP2C9ALDH1A1 | |
| SCHEMBL6342860 | 0.72 | KDM4E (0.34) | ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL11660485 | 0.71 | TAAR1 (0.42) | PTGS1PTGS2CYP2C9L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644892-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1995-03-29 | — | — | EP | disclosed |
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |