SCHEMBL7354716

SCHEMBL7354716

CC1=CN=C(c2ccccc2)[N]1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.37
ALDH1A1 P00352 2/20 0.35
CYP2A6 P11509 1/20 0.34
CYP2B6 P20813 1/20 0.34
NPC1 O15118 4/20 0.33
RAB9A P51151 4/20 0.33
MAPK1 P28482 1/20 0.33
AKT2 P31751 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
CHEK1 O14757 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
AKT1 P31749 1/20 0.32
BRD4 O60885 1/20 0.32
BRD2 P25440 1/20 0.32
POLB P06746 1/20 0.32
HPGD P15428 1/20 0.32
NFKB1 P19838 1/20 0.32
NFKB2 Q00653 1/20 0.32
RELA Q04206 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL482254 0.68 L3MBTL1 (0.37) L3MBTL1ALDH1A1CYP2A6CYP2B6NPC1
SCHEMBL7682660 0.64 ALDH1A1 (0.47) L3MBTL1ALDH1A1NPC1RAB9AMAPK1
SCHEMBL21151453 0.63 ALDH1A1 (0.53) L3MBTL1ALDH1A1NPC1RAB9AMAPK1
Biphenyl SCHEMBL598676 0.61 ALDH1A1 (0.90) ALDH1A1CYP2A6CYP2B6NPC1RAB9A
Biphenyl SCHEMBL5087469 0.61 ALDH1A1 (0.90) ALDH1A1CYP2A6CYP2B6NPC1RAB9A
Biphenyl SCHEMBL7411979 0.58 ALDH1A1 (0.82) ALDH1A1CYP2A6CYP2B6NPC1RAB9A
Biphenyl SCHEMBL7993413 0.58 ALDH1A1 (0.82) ALDH1A1CYP2A6CYP2B6NPC1RAB9A
Biphenyl SCHEMBL653702 0.58 ALDH1A1 (0.82) ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2
Biphenyl SCHEMBL27587661 0.57 ACHE (0.71) L3MBTL1ALDH1A1CYP2A6CYP2B6NPC1
Biphenyl SCHEMBL164 0.57 ALDH1A1 (1.00) ALDH1A1CYP2A6CYP2B6NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999032454-A9 NITROGEN CONTAINING HETEROAROMATICS WITH ORTHO-SUBSTITUTED P1'S AS FACTOR XA INHIBITORS DU PONT PHARM CO (US) 2001-05-31 WO disclosed
EP-1064270-A2 DISUBSTITUTED PYRAZOLINES AND TRIAZOLINES AS FACTOR XA INHIBITORS Du Pont Pharmaceuticals Company (US) 2001-01-03 EP disclosed
EP-1042299-A1 NITROGEN CONTAINING HETEROAROMATICS WITH ORTHO-SUBSTITUTED P1'S AS FACTOR XA INHIBITORS Du Pont Pharmaceuticals Company (US) 2000-10-11 EP disclosed
WO-1999050255-A2 DISUBSTITUTED PYRAZOLINES AND TRIAZOLINES AS FACTOR XA INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 1999-10-07 WO disclosed
EP-0946528-A2 OXYGEN OR SULFUR CONTAINING 5-MEMBERED HETEROAROMATICS AS FACTOR Xa INHIBITORS Du Pont Pharmaceuticals Company (US) 1999-10-06 EP disclosed
EP-0946508-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS Du Pont Pharmaceuticals Company (US) 1999-10-06 EP disclosed
WO-1999032454-A1 NITROGEN CONTAINING HETEROAROMATICS WITH ORTHO-SUBSTITUTED P1'S AS FACTOR XA INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 1999-07-01 WO disclosed
WO-1998028282-A2 OXYGEN OR SULFUR CONTAINING 5-MEMBERED HETEROAROMATICS AS FACTOR Xa INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 1998-07-02 WO disclosed
WO-1998028269-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 1998-07-02 WO disclosed