Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7356935 | 0.92 | ELANE (0.31) | ELANEMAPT | |
| SCHEMBL7357388 | 0.92 | MDM2 (0.33) | MDM2TP53 | |
| SCHEMBL7355407 | 0.91 | MDM2 (0.33) | MDM2TP53 | |
| SCHEMBL7362794 | 0.90 | MAPT (0.36) | MDM2TP53MAPT | |
| SCHEMBL7324070 | 0.89 | ELANE (0.36) | ELANEMDM2TP53CYP3A4 | |
| SCHEMBL8843197 | 0.84 | MAPT (0.32) | ELANEMDM2MAPT | |
| SCHEMBL7363260 | 0.84 | ITGB3 (0.34) | MAPT | |
| SCHEMBL7356241 | 0.84 | MDM2 (0.32) | MDM2TP53 | |
| SCHEMBL7354809 | 0.83 | ITGB3 (0.34) | MDM2TP53 | |
| SCHEMBL7333912 | 0.82 | ELANE (0.39) | ELANEMDM2TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0610334-B1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII B III A RECEPTOR | GENENTECH INC (US) | 1996-01-24 | — | — | EP | disclosed |
| EP-0610334-A1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII b?III a? RECEPTOR. | GENENTECH INC (US) | 1994-08-17 | — | — | EP | disclosed |
| WO-1993008174-A1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR | GENENTECH, INC. (US) | 1993-04-29 | — | — | WO | disclosed |