Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355407 | 0.92 | MDM2 (0.33) | MDM2TP53KDM4EALDH1A1 | |
| SCHEMBL7354809 | 0.92 | ITGB3 (0.34) | MDM2TP53F2F10ITGB3 | |
| SCHEMBL7356935 | 0.91 | ELANE (0.31) | F2F10ITGB3ITGA2B | |
| SCHEMBL7357418 | 0.90 | MAPT (0.35) | MDM2TP53ALDH1A1F2F10 | |
| SCHEMBL7318695 | 0.90 | TNF (0.36) | MDM2TP53KDM4EALDH1A1F10 | |
| SCHEMBL7357388 | 0.85 | MDM2 (0.33) | MDM2TP53KDM4EALDH1A1F2 | |
| SCHEMBL7331017 | 0.85 | KDM4E (0.31) | MDM2TP53KDM4EALDH1A1F2 | |
| SCHEMBL7357194 | 0.84 | MEN1 (0.34) | — | |
| SCHEMBL7354728 | 0.84 | ELANE (0.33) | MDM2TP53 | |
| SCHEMBL7362794 | 0.83 | MAPT (0.36) | MDM2TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0610334-B1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII B III A RECEPTOR | GENENTECH INC (US) | 1996-01-24 | — | — | EP | disclosed |
| EP-0610334-A1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII b?III a? RECEPTOR. | GENENTECH INC (US) | 1994-08-17 | — | — | EP | disclosed |
| WO-1993008174-A1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR | GENENTECH, INC. (US) | 1993-04-29 | — | — | WO | disclosed |