Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 11/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357418 | 0.92 | MAPT (0.35) | MAPTPKMALDH1A1MAPK1NPSR1 | |
| SCHEMBL7357388 | 0.91 | MDM2 (0.33) | ALDH1A1MDM2TP53 | |
| SCHEMBL7355407 | 0.90 | MDM2 (0.33) | ALDH1A1MDM2TP53 | |
| SCHEMBL7323174 | 0.90 | MAPT (0.38) | MAPTPKMALDH1A1MAPK1NPSR1 | |
| SCHEMBL7354728 | 0.90 | ELANE (0.33) | MAPTMDM2TP53 | |
| SCHEMBL7329383 | 0.84 | MAPT (0.38) | MAPTPKMALDH1A1MAPK1NPSR1 | |
| SCHEMBL7357140 | 0.84 | MAPT (0.37) | MAPTPKMALDH1A1MAPK1NPSR1 | |
| SCHEMBL7331084 | 0.84 | MDM2 (0.41) | MAPTPKMALDH1A1MAPK1NPSR1 | |
| SCHEMBL7356241 | 0.83 | MDM2 (0.32) | ALDH1A1MDM2TP53 | |
| SCHEMBL7354809 | 0.83 | ITGB3 (0.34) | MDM2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0610334-B1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII B III A RECEPTOR | GENENTECH INC (US) | 1996-01-24 | — | — | EP | disclosed |
| WO-1993008174-A1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR | GENENTECH, INC. (US) | 1993-04-29 | — | — | WO | disclosed |