Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353378 | 0.90 | ELANE (0.40) | ELANEMAOAMAOBCNR2GAA | |
| SCHEMBL20512123 | 0.81 | TACR1 (0.40) | MAOBNPSR1MEN1TSHRKMT2A | |
| SCHEMBL576739 | 0.80 | L3MBTL1 (0.42) | ELANEMAOAMAOBGAANPSR1 | |
| SCHEMBL11696413 | 0.80 | CNR2 (0.43) | ELANEMAOAMAOBCNR2GAA | |
| SCHEMBL14558127 | 0.78 | PARP1 (0.34) | GAAL3MBTL1 | |
| SCHEMBL577037 | 0.75 | LMNA (0.41) | ELANEMAOAMAOBGAANPSR1 | |
| SCHEMBL29269106 | 0.75 | MAOA (0.41) | ELANEMAOAMAOBGAABACE1 | |
| SCHEMBL11481803 | 0.73 | GRIN1 (0.42) | ELANEMAOAMAOBGAATSHR | |
| SCHEMBL577460 | 0.73 | TSHR (0.36) | NPSR1TSHRLMNA | |
| SCHEMBL18268924 | 0.73 | TSHR (0.36) | NPSR1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999036419-A1 | SUBSTITUTED LACTONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-07-22 | — | — | WO | claimed |
| WO-1999036419-A1 | SUBSTITUTED LACTONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-07-22 | — | — | WO | disclosed |