Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9556577 | 0.86 | LTA4H (0.37) | HPGD | |
| SCHEMBL7354901 | 0.84 | HRH4 (0.44) | HRH4RENCYP19A1ALDH1A1HPGD | |
| SCHEMBL9556425 | 0.79 | LTA4H (0.43) | — | |
| SCHEMBL9556709 | 0.79 | LTA4H (0.34) | RENHPGD | |
| SCHEMBL9556548 | 0.78 | REN (0.35) | REN | |
| SCHEMBL9556729 | 0.77 | REN (0.44) | REN | |
| SCHEMBL9556344 | 0.76 | HRH4 (0.58) | HRH4CYP19A1 | |
| SCHEMBL9556396 | 0.76 | LTA4H (0.41) | — | |
| SCHEMBL9556549 | 0.76 | REN (0.45) | RENALDH1A1HPGD | |
| SCHEMBL9556448 | 0.76 | GAA (0.43) | RENALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | claimed |
| WO-1992022313-A1 | RENIN INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-12-23 | — | — | WO | claimed |
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | disclosed |