Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.57 |
| ▸ | FKBP1A | P62942 | 8/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355087 | 0.88 | ACE (0.60) | ACEACE2 | |
| SCHEMBL7355184 | 0.87 | ACE (0.57) | ACEFKBP1AGAAACE2 | |
| SCHEMBL6439093 | 0.84 | ACE (0.62) | ACEFKBP1AACE2 | |
| SCHEMBL7348938 | 0.84 | CAPN1 (0.57) | — | |
| SCHEMBL7348952 | 0.84 | CAPN1 (0.57) | — | |
| SCHEMBL7347204 | 0.82 | OPRM1 (0.49) | ACEGAAACE2 | |
| SCHEMBL8365677 | 0.82 | ACE (0.57) | ACEFKBP1A | |
| SCHEMBL8364232 | 0.82 | ACE (0.57) | ACEFKBP1A | |
| SCHEMBL7356132 | 0.82 | F2 (0.51) | ACEGAAACE2 | |
| SCHEMBL7356122 | 0.82 | F2 (0.51) | ACEGAAACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644892-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1995-03-29 | — | — | EP | disclosed |
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |