Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.60 |
| ▸ | HTR7 | P34969 | 6/20 | 0.60 |
| ▸ | DRD2 | P14416 | 9/20 | 0.57 |
| ▸ | DRD3 | P35462 | 7/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.57 |
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | HTR6 | P50406 | 3/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343240 | 0.90 | DRD2 (0.59) | HTR1AHTR7DRD2DRD3KCNH2 | |
| SCHEMBL7351802 | 0.90 | HTR1A (0.58) | HTR1AHTR7DRD2DRD3HTR2A | |
| SCHEMBL7343614 | 0.85 | KCNH2 (0.60) | DRD2DRD3KCNH2HTR2ADRD4 | |
| SCHEMBL6924603 | 0.81 | DRD3 (0.55) | HTR1AHTR7DRD2DRD3HTR6 | |
| SCHEMBL7344989 | 0.80 | HTR1A (0.64) | HTR1AHTR7DRD2DRD3DRD4 | |
| SCHEMBL7350903 | 0.79 | KCNH2 (0.76) | HTR1ADRD2DRD3KCNH2MAPT | |
| SCHEMBL9299310 | 0.78 | DRD2 (0.54) | HTR1ADRD2DRD3KCNH2HTR2A | |
| SCHEMBL6926651 | 0.78 | DRD2 (0.55) | HTR1AHTR7DRD2DRD3DRD4 | |
| SCHEMBL7353702 | 0.77 | KCNH2 (0.65) | DRD2DRD3KCNH2HTR2ADRD4 | |
| SCHEMBL7347716 | 0.77 | DRD3 (0.61) | DRD2DRD3KCNH2HTR2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536279-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1993-04-14 | — | — | EP | claimed |
| WO-1992000282-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1992-01-09 | — | — | WO | claimed |
| US-5281594-A | Dopamine antagonist, Parkinson's disease and drug addiction | THE UPJOHN COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0536279-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1992000282-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1992-01-09 | — | — | WO | disclosed |