Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.64 |
| ▸ | HTR7 | P34969 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 4/20 | 0.61 |
| ▸ | DRD3 | P35462 | 4/20 | 0.61 |
| ▸ | DRD5 | P21918 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343240 | 0.90 | DRD2 (0.59) | HTR1AHTR7MEN1KMT2ACYP1A2 | |
| SCHEMBL7351802 | 0.89 | HTR1A (0.58) | HTR1AHTR7DRD2DRD3ADRA1D | |
| SCHEMBL6924599 | 0.86 | ADRA1A (0.57) | HTR1ADRD2DRD3ADRA1DADRA1A | |
| SCHEMBL6924603 | 0.85 | DRD3 (0.55) | HTR1AHTR7DRD2DRD3ALDH1A1 | |
| SCHEMBL7068893 | 0.83 | KCNH2 (0.64) | HTR1AHTR7DRD2DRD3DRD5 | |
| SCHEMBL7346970 | 0.82 | KCNH2 (0.67) | HTR1AHTR7DRD2DRD3ADRA1A | |
| SCHEMBL6926592 | 0.81 | ADRA1A (0.52) | HTR1ADRD2DRD3ALDH1A1ADRA1D | |
| SCHEMBL7344855 | 0.81 | DRD2 (0.63) | HTR1AHTR7DRD2DRD3DRD5 | |
| SCHEMBL6926651 | 0.81 | DRD2 (0.55) | HTR1AHTR7DRD2DRD3ALDH1A1 | |
| SCHEMBL7355246 | 0.80 | HTR1A (0.60) | HTR1AHTR7DRD2DRD3ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281594-A | Dopamine antagonist, Parkinson's disease and drug addiction | THE UPJOHN COMPANY (US) | 1994-01-25 | — | — | US | claimed |
| EP-0536279-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1993-04-14 | — | — | EP | claimed |
| WO-1992000282-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1992-01-09 | — | — | WO | claimed |
| US-5281594-A | Dopamine antagonist, Parkinson's disease and drug addiction | THE UPJOHN COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| US-5281594-A | Dopamine antagonist, Parkinson's disease and drug addiction | THE UPJOHN COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0536279-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1993-04-14 | — | — | EP | disclosed |
| EP-0536279-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1992000282-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1992-01-09 | — | — | WO | disclosed |
| WO-1992000282-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1992-01-09 | — | — | WO | disclosed |