Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.81 |
| ▸ | MMP9 | P14780 | 2/20 | 0.81 |
| ▸ | MMP13 | P45452 | 2/20 | 0.81 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.77 |
| ▸ | TAS2R14 | Q9NYV8 | 5/20 | 0.54 |
| ▸ | PTGES | O14684 | 2/20 | 0.52 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.52 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7379371 | 1.00 | MMP1 (0.81) | MMP1MMP9MMP13KCNA5TAS2R14 | |
| SCHEMBL7355335 | 1.00 | MMP1 (0.81) | MMP1MMP9MMP13KCNA5TAS2R14 | |
| SCHEMBL7355340 | 1.00 | MMP1 (0.81) | MMP1MMP9MMP13KCNA5TAS2R14 | |
| SCHEMBL7379373 | 1.00 | MMP1 (0.81) | MMP1MMP9MMP13KCNA5TAS2R14 | |
| Hydroxyamine SCHEMBL7457004 | 0.98 | MMP1 (0.78) | MMP1MMP9MMP13KCNA5TAS2R14 | |
| Hydroxyamine SCHEMBL7411103 | 0.98 | MMP1 (0.78) | MMP1MMP9MMP13KCNA5TAS2R14 | |
| Hydroxyamine SCHEMBL7411106 | 0.98 | MMP1 (0.78) | MMP1MMP9MMP13KCNA5TAS2R14 | |
| Hydroxyamine SCHEMBL7457010 | 0.98 | MMP1 (0.78) | MMP1MMP9MMP13KCNA5TAS2R14 | |
| Hydroxyamine SCHEMBL7411112 | 0.98 | MMP1 (0.78) | MMP1MMP9MMP13KCNA5TAS2R14 | |
| SCHEMBL7615080 | 0.90 | MMP9 (1.00) | MMP1MMP9MMP13KCNA5TAS2R14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934259-B1 | BETA-SULFONAMIDO HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2002-09-18 | — | — | EP | disclosed |
| US-6326516-B1 | RHEUMATIC DISEASES; SEPSIS; ANTIULCER AGENTS | AMERICAN CYANAMID COMPANY | 2001-12-04 | — | — | US | disclosed |
| EP-1147078-A1 | ACETYLENIC (BETA)-SULFONAMIDO AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044711-A1 | ACETYLENIC $G(b)-SULFONAMIDO AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |
| US-5977408-A | USEFUL FOR THE TREATMENT OF DISEASES IN WHICH THESE ENZYMES ARE IMPLICATED SUCH AS ARTHRITIS, TUMOR GROWTH AND METASTASIS, ANGIOGENESIS, TISSUE ULCERATION, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, PROTEINURIA | AMERICAN CYANAMID COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0934259-A1 | BETA-SULFONAMIDO HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998016506-A1 | BETA-SULFONAMIDO HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |