Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 8/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.63 |
| ▸ | USP2 | O75604 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.63 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 4/20 | 0.58 |
| ▸ | TYR | P14679 | 4/20 | 0.58 |
| ▸ | MAOA | P21397 | 3/20 | 0.58 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5707772 | 0.83 | MAOB (0.83) | MEN1KMT2AUSP2KDM4EMAPT | |
| SCHEMBL5707779 | 0.83 | MAOB (0.83) | MEN1KMT2AUSP2KDM4EMAPT | |
| SCHEMBL21082590 | 0.83 | STK17B (0.66) | PIK3C3MEN1KMT2AUSP2KDM4E | |
| SCHEMBL6963496 | 0.76 | MEN1 (0.80) | MEN1KMT2AUSP2KDM4EMAPT | |
| SCHEMBL6963493 | 0.76 | MEN1 (0.80) | MEN1KMT2AUSP2KDM4EMAPT | |
| SCHEMBL25426134 | 0.76 | MAOB (0.79) | MEN1KMT2AUSP2KDM4EMAPT | |
| SCHEMBL6807842 | 0.76 | USP2 (0.67) | MEN1KMT2AUSP2KDM4EMAPT | |
| SCHEMBL6807845 | 0.76 | USP2 (0.67) | MEN1KMT2AUSP2KDM4EMAPT | |
| SCHEMBL6965152 | 0.74 | MAOB (0.78) | MEN1KMT2AUSP2KDM4EMAPT | |
| SCHEMBL6965147 | 0.74 | MAOB (0.78) | MEN1KMT2AUSP2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6307051-B1 | UROKINASE-TYPE PLASMINOGEN ACTIVATOR ANTAGONISTS AND HAVE ANTITUMOR AND ANTIMETASTATIC ACTIVITY. | ROCHE DIAGNOSTICS GMBH (DE) | 2001-10-23 | — | — | US | disclosed |
| EP-1026165-A1 | O-substituted Hydroxycoumaranone derivatives as antitumor and antimetastatic agents | Roche Diagnostics GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |
| US-4486442-A | ANTIANAPHYLACTIC | BOEHRINGER MANNHEIM GMBH (DE) | 1984-12-04 | — | — | US | disclosed |