Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 17/20 | 0.57 |
| ▸ | METAP1 | P53582 | 9/20 | 0.57 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | FAP | Q12884 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7360183 | 0.99 | METAP2 (0.56) | METAP2METAP1DPP4FAPDPP8 | |
| SCHEMBL14984955 | 0.87 | METAP2 (0.44) | METAP2METAP1DPP4FAPDPP8 | |
| SCHEMBL12022087 | 0.86 | METAP2 (0.43) | METAP2METAP1DPP4FAPDPP8 | |
| SCHEMBL21928685 | 0.86 | METAP2 (0.43) | METAP2METAP1DPP4FAPDPP8 | |
| SCHEMBL7362423 | 0.82 | METAP2 (0.63) | METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7352923 | 0.81 | METAP2 (0.62) | METAP2METAP1 | |
| SCHEMBL7360854 | 0.81 | METAP2 (0.60) | METAP2METAP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7349814 | 0.80 | METAP2 (0.58) | METAP2METAP1ALDH1A1 | |
| SCHEMBL23710451 | 0.78 | METAP2 (0.38) | METAP2METAP1DPP4FAPDPP8 | |
| SCHEMBL6477759 | 0.78 | METAP2 (0.72) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | claimed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |