Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 6/20 | 0.38 |
| ▸ | METAP1 | P53582 | 6/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 6/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14984955 | 0.88 | METAP2 (0.44) | METAP2METAP1SCN9ADPP4ALDH1A1 | |
| SCHEMBL21928685 | 0.81 | METAP2 (0.43) | METAP2METAP1SCN9ADPP4ALDH1A1 | |
| SCHEMBL12022087 | 0.81 | METAP2 (0.43) | METAP2METAP1SCN9ADPP4ALDH1A1 | |
| SCHEMBL7355425 | 0.78 | METAP2 (0.57) | METAP2METAP1DPP4ALDH1A1DPP8 | |
| Hydrochloric Acid SCHEMBL7360183 | 0.78 | METAP2 (0.56) | METAP2METAP1DPP4ALDH1A1DPP8 | |
| SCHEMBL18596854 | 0.67 | PKM (0.40) | METAP2METAP1CTSDMEN1KMT2A | |
| SCHEMBL23710550 | 0.65 | CTSD (0.45) | METAP2METAP1ALDH1A1CTSD | |
| SCHEMBL15200377 | 0.65 | METAP2 (0.48) | METAP2METAP1ALDH1A1CTSDMEN1 | |
| SCHEMBL7362423 | 0.65 | METAP2 (0.63) | METAP2METAP1MEN1KMT2A | |
| SCHEMBL14985000 | 0.65 | METAP2 (0.57) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858385-A2 | POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF | Syndevrx, Inc. (US) | 2021-08-04 | — | — | EP | disclosed |