SCHEMBL7355430

SCHEMBL7355430

CCOC(=O)CN(C(=O)c1ccccn1)c1ccc2[nH]c(C)c(C(=O)Cc3ccc(C#N)cc3)c2c1

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.36
POLB P06746 1/20 0.36
PKM P14618 1/20 0.34
KDM4E B2RXH2 4/20 0.34
USP2 O75604 1/20 0.34
HPGD P15428 1/20 0.34
GAA P10253 3/20 0.33
MAPT P10636 3/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
AR P10275 1/20 0.33
TDP1 Q9NUW8 1/20 0.32
ALOX15 P16050 1/20 0.32
USP14 P54578 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7360090 0.85 KDM4E (0.37) ALDH1A1KDM4EHPGDMAPTMEN1
SCHEMBL7362439 0.81 LMNA (0.38) KDM4EMAPTTDP1USP14
Hydrochloric Acid SCHEMBL7352102 0.79 F2 (0.39) ALDH1A1POLBPKMUSP2HPGD
SCHEMBL7355838 0.70 F2 (0.40) ALDH1A1POLBPKMGAAMAPT
SCHEMBL7352839 0.70 ALDH1A1 (0.36) ALDH1A1POLBPKMGAAMAPT
Hydrochloric Acid SCHEMBL7356747 0.69 F2 (0.37) ALDH1A1POLBGAAMAPT
SCHEMBL8109484 0.69 NQO2 (0.53) ALDH1A1PKMKDM4EGAAMAPT
Hydrochloric Acid SCHEMBL7355682 0.68 F10 (0.44)
Hydrochloric Acid SCHEMBL7360761 0.68 F2 (0.44)
SCHEMBL7353120 0.68 NTRK1 (0.36) MAPTTDP1USP14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999028297-A1 SUBSTITUTED INDOLES, HAVING A THROMBIN INHIBITING EFFECT BOEHRINGER INGELHEIM PHARMA KG (DE) 1999-06-10 WO disclosed