SCHEMBL7355486

SCHEMBL7355486

COC(=O)[C@@H]1CCCN1Cc1cccc(C(=O)NO)c1N(C)S(=O)(=O)c1ccc(OC)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MMP9 P14780 20/20 1.00
MMP13 P45452 20/20 1.00
MMP1 P03956 19/20 1.00
ADAM17 P78536 17/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7348749 1.00 MMP9 (1.00) MMP9MMP13MMP1ADAM17
SCHEMBL7320048 0.91 MMP1 (0.84) MMP9MMP13MMP1ADAM17
SCHEMBL7318146 0.88 MMP1 (0.78) MMP9MMP13MMP1ADAM17
SCHEMBL7554630 0.88 MMP1 (0.78) MMP9MMP13MMP1ADAM17
SCHEMBL7315614 0.84 MMP9 (0.86) MMP9MMP13MMP1ADAM17
SCHEMBL7348743 0.82 MMP13 (0.70) MMP9MMP13MMP1ADAM17
SCHEMBL6852400 0.81 MMP9 (1.00) MMP9MMP13MMP1ADAM17
SCHEMBL7325385 0.80 MMP9 (1.00) MMP9MMP13MMP1ADAM17
SCHEMBL27563881 0.79 MMP1 (0.65) MMP9MMP13MMP1ADAM17
SCHEMBL27510260 0.76 MMP1 (0.61) MMP9MMP13MMP1ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0938471-B1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID CO (US) 2001-12-12 EP disclosed
EP-0977756-A1 PYRAZOLOPYRIMIDINONES WHICH INHIBIT TYPE 5 CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE (cGMP PDE5) FOR THE TREATMENT OF SEXUAL DYSFUNCTION Pfizer Limited (GB) 2000-02-09 EP disclosed
EP-0938471-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS American Cyanamid Company (US) 1999-09-01 EP disclosed
WO-1998049166-A1 PYRAZOLOPYRIMIDINONES WHICH INHIBIT TYPE 5 CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE (cGMP PDE5) FOR THE TREATMENT OF SEXUAL DYSFUNCTION PFIZER LIMITED (GB) 1998-11-05 WO disclosed
WO-1998016503-A2 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1998-04-23 WO disclosed