Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.50 |
| ▸ | TUBB | P07437 | 3/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.50 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.50 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.50 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9352795 | 0.90 | LDHA (0.60) | ALOX15ALOX12GAALDHAMEN1 | |
| SCHEMBL28992695 | 0.82 | ALOX15 (0.54) | ALOX15ALOX12GAACYP3A4TSHR | |
| SCHEMBL30387035 | 0.82 | ALOX15 (0.54) | ALOX15ALOX12GAACYP3A4TSHR | |
| SCHEMBL27512733 | 0.78 | LDHA (0.56) | CYP3A4CYP1A2LDHAKMT2A | |
| SCHEMBL7360593 | 0.78 | LDHA (0.56) | CYP3A4CYP1A2LDHAKMT2A | |
| SCHEMBL7354148 | 0.77 | CA12 (0.45) | ALOX15TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL5724393 | 0.77 | GAA (0.73) | ALOX15ALOX12GAATUBB1TUBB4A | |
| SCHEMBL28622516 | 0.77 | ALOX15 (0.60) | ALOX15ALOX12GAATUBB1TUBB4A | |
| SCHEMBL16973420 | 0.77 | LDHA (0.62) | ALOX15ALOX12LDHALMNAKDM4E | |
| SCHEMBL490932 | 0.76 | LDHA (0.76) | ALOX15ALOX12GAATUBB1TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005448-A2 | NOVEL INHIBITORS OF AGGRECANASE AND MATRIX METALLOPROTEINASES FOR THE TREATMENT OF ARTHRITIS | Du Pont Pharmaceuticals Company (US) | 2000-06-07 | — | — | EP | claimed |
| WO-1999009000-A2 | NOVEL INHIBITORS OF AGGRECANASE AND MATRIX METALLOPROTEINASES FOR THE TREATMENT OF ARTHRITIS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-02-25 | — | — | WO | claimed |