Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 2/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.68 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.57 |
| ▸ | TUBB | P07437 | 3/20 | 0.57 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.57 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.57 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.57 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.57 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.57 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.57 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.57 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.57 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.57 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.57 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.57 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6378609 | 0.87 | ALOX15 (0.64) | LDHAALOX15ALOX12GAATUBB1 | |
| SCHEMBL17963708 | 0.87 | KDM6B (0.66) | LDHAALOX15ALOX12GAATUBB1 | |
| SCHEMBL30912683 | 0.87 | KDM6B (0.66) | LDHAALOX15ALOX12GAATUBB1 | |
| SCHEMBL491190 | 0.87 | LDHA (0.76) | LDHAALOX15ALOX12GAACYP3A4 | |
| SCHEMBL490731 | 0.86 | LDHA (1.00) | LDHAALOX15ALOX12GAALMNA | |
| SCHEMBL23761314 | 0.86 | ALOX15 (0.62) | LDHAALOX15ALOX12GAATUBB1 | |
| SCHEMBL865455 | 0.86 | SLC7A5 (0.67) | LDHAALOX15ALOX12GAATUBB1 | |
| SCHEMBL8009087 | 0.86 | SLC7A5 (0.67) | LDHAALOX15ALOX12GAATUBB1 | |
| SCHEMBL865456 | 0.86 | SLC7A5 (0.67) | LDHAALOX15ALOX12GAATUBB1 | |
| SCHEMBL490506 | 0.84 | ALOX15 (0.60) | LDHAALOX15ALOX12GAATUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268293-B2 | Using compounds which do not themselves exhibit significant UV absorption in the UV-A or UV-B region, but are reactive under use conditions, such as 4-hydroxyphenylpropionic acid, or 2-ethylhexyl 4-hydroxy-3,5-dimethoxycinnamate, or polysiloxanes which contain benzylidenemalonic acid derivatives | MERCK PATENT GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| US-8106233-B2 | Applying di-2-ethylhexyl 4-hydroxy-3,5-dimethoxy-benzylmalonate; protective action against UV rays, oxidative stress on body cells, counters skin ageing | MERCK PATENT GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20080171004-A1 | Using compounds which do not themselves exhibit significant UV absorption in the UV-A or UV-B region, but are reactive under use conditions, such as 4-hydroxyphenylpropionic acid, or 2-ethylhexyl 4-hydroxy-3,5-dimethoxycinnamate, or polysiloxanes which contain benzylidenemalonic acid derivatives | MERCK PATENT GMBH (DE) | 2008-07-17 | — | — | US | disclosed |
| US-20080152603-A1 | Antioxidants | SUSONITY Commercial GmbH (DE) | 2008-06-26 | — | — | US | disclosed |
| EP-1871735-A1 | ANTIOXIDANTS | Merck Patent GmbH (DE) | 2008-01-02 | — | — | EP | disclosed |
| EP-1871339-A1 | UV PROTECTION | Merck Patent GmbH (DE) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006111233-A1 | ANTIOXIDANTS | MERCK PATENT GMBH (DE) | 2006-10-26 | — | — | WO | disclosed |
| WO-2006111234-A1 | UV PROTECTION | MERCK PATENT GMBH (DE) | 2006-10-26 | — | — | WO | disclosed |
| EP-1266888-A1 | QUINOLINE DERIVATIVES AND MEDICINAL USE THEREOF | Mitsui Chemicals, Inc. (JP) | 2002-12-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080152603-A1 | Antioxidants | GPX4, GPX1, CAT | LDHA 612/4885ALOX15 156/4885ALOX12 140/4885 |
| US-20080171004-A1 | Using compounds which do not themselves exhibit significant UV absorption in the UV-A or UV-B region, but are reactive under use conditions, such as 4-hydroxyphenylpropionic acid, or 2-ethylhexyl 4-hydroxy-3,5-dimethoxycinnamate, or polysiloxanes which contain benzylidenemalonic acid derivatives | HPD, HAAO, UGT1A6 | LDHA 843/4885ALOX15 1546/4885ALOX12 1448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.