Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 4/20 | 0.69 |
| ▸ | CNR1 | P21554 | 3/20 | 0.68 |
| ▸ | CNR2 | P34972 | 2/20 | 0.63 |
| ▸ | KDM4A | O75164 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8508760 | 0.94 | MMP8 (0.62) | MMP8CNR1CNR2KDM4ACYP2D6 | |
| SCHEMBL8507424 | 0.81 | NAAA (0.72) | MMP8KMT2A | |
| SCHEMBL7350719 | 0.81 | NAAA (0.72) | MMP8KMT2A | |
| SCHEMBL8508884 | 0.79 | MMP8 (1.00) | MMP8CNR1CNR2KDM4ACYP2D6 | |
| SCHEMBL7357043 | 0.79 | MMP8 (1.00) | MMP8CNR1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL14861138 | 0.77 | POLB (0.61) | CNR1CNR2KDM4ACYP2D6CYP2C9 | |
| SCHEMBL13396879 | 0.76 | KMT2A (1.00) | MMP8CNR1KDM4ACYP2D6CYP2C9 | |
| SCHEMBL8507376 | 0.76 | MMP8 (1.00) | MMP8CYP2D6CYP2C9CYP2C19KMT2A | |
| SCHEMBL8507449 | 0.76 | MMP8 (0.54) | MMP8EPHX2 | |
| SCHEMBL4151569 | 0.76 | POLB (0.64) | CNR1KDM4ACYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009736-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | Roche Diagnostics GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| EP-0911319-A1 | Malonic acid based matrix metalloproteinase inhibitors | Roche Diagnostics GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |
| WO-1999011608-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-03-11 | — | — | WO | disclosed |