Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 4/20 | 0.72 |
| ▸ | MMP8 | P22894 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TLR2 | O60603 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507424 | 1.00 | NAAA (0.72) | NAAAMMP8LMNAPAX8EPHX1 | |
| SCHEMBL8508760 | 0.84 | MMP8 (0.62) | MMP8KMT2A | |
| SCHEMBL2333785 | 0.82 | NAAA (0.75) | NAAALMNAPAX8EPHX1ALDH1A1 | |
| SCHEMBL6434483 | 0.82 | NAAA (0.75) | NAAALMNAPAX8EPHX1ALDH1A1 | |
| SCHEMBL6258955 | 0.82 | NAAA (0.97) | NAAALMNAPAX8EPHX1ALDH1A1 | |
| SCHEMBL7355686 | 0.81 | MMP8 (0.69) | MMP8KMT2A | |
| SCHEMBL7746674 | 0.81 | NAAA (0.60) | NAAALMNAPAX8HTTMEN1 | |
| SCHEMBL2334318 | 0.80 | NAAA (0.72) | NAAALMNAPAX8 | |
| SCHEMBL7355911 | 0.80 | MMP8 (0.51) | NAAAMMP8ALDH1A1MMP1MMP3 | |
| SCHEMBL4982670 | 0.79 | NAAA (0.71) | NAAALMNAPAX8EPHX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009736-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | Roche Diagnostics GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| EP-0911319-A1 | Malonic acid based matrix metalloproteinase inhibitors | Roche Diagnostics GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |
| WO-1999011608-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-03-11 | — | — | WO | disclosed |