Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 12/20 | 0.49 |
| ▸ | FEN1 | P39748 | 12/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355759 | 1.00 | ALOX5AP (0.49) | ALOX5APFEN1MMP3OPRM1OPRK1 | |
| SCHEMBL6974699 | 0.82 | ALOX5AP (0.53) | ALOX5APFEN1MMP3OPRM1OPRK1 | |
| SCHEMBL6771873 | 0.80 | EDNRA (0.58) | ALOX5APFEN1OPRM1OPRK1EDNRB | |
| SCHEMBL7190899 | 0.78 | ALOX5AP (0.55) | ALOX5APFEN1MMP3OPRM1OPRK1 | |
| SCHEMBL7350035 | 0.77 | MME (0.50) | MMP1MMP9 | |
| SCHEMBL6630002 | 0.77 | ALOX5AP (0.57) | ALOX5APFEN1OPRM1OPRK1 | |
| SCHEMBL7355749 | 0.76 | SCN9A (0.48) | ALOX5APFEN1MMP3OPRM1OPRK1 | |
| SCHEMBL8429813 | 0.75 | ALOX5AP (0.54) | ALOX5APFEN1 | |
| SCHEMBL7352933 | 0.74 | MME (0.50) | MMP2MMP9 | |
| SCHEMBL7266847 | 0.74 | ALOX5AP (0.55) | ALOX5APFEN1MMP3OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005448-A2 | NOVEL INHIBITORS OF AGGRECANASE AND MATRIX METALLOPROTEINASES FOR THE TREATMENT OF ARTHRITIS | Du Pont Pharmaceuticals Company (US) | 2000-06-07 | — | — | EP | claimed |
| WO-1999009000-A2 | NOVEL INHIBITORS OF AGGRECANASE AND MATRIX METALLOPROTEINASES FOR THE TREATMENT OF ARTHRITIS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-02-25 | — | — | WO | claimed |
| EP-1005448-A2 | NOVEL INHIBITORS OF AGGRECANASE AND MATRIX METALLOPROTEINASES FOR THE TREATMENT OF ARTHRITIS | Du Pont Pharmaceuticals Company (US) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999009000-A2 | NOVEL INHIBITORS OF AGGRECANASE AND MATRIX METALLOPROTEINASES FOR THE TREATMENT OF ARTHRITIS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-02-25 | — | — | WO | disclosed |