Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 4/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2082408 | 0.81 | ADRA2A (0.53) | AOC3ADRA1AADRA2AL3MBTL1ALDH1A1 | |
| SCHEMBL7148668 | 0.81 | ADRA2A (0.53) | AOC3ADRA1AADRA2AL3MBTL1ALDH1A1 | |
| SCHEMBL31143084 | 0.81 | ADRA2A (0.53) | AOC3ADRA1AADRA2AL3MBTL1ALDH1A1 | |
| SCHEMBL7356118 | 0.81 | ALDH1A1 (0.38) | ADRA1AADRA2AL3MBTL1ALDH1A1TAAR1 | |
| SCHEMBL3183689 | 0.79 | ALDH1A1 (0.44) | AOC3ADRA1AADRA2AL3MBTL1ALDH1A1 | |
| SCHEMBL6448011 | 0.79 | ALDH1A1 (0.44) | AOC3L3MBTL1ALDH1A1GAA | |
| SCHEMBL6128581 | 0.79 | ALDH1A1 (0.44) | AOC3ADRA1AADRA2AL3MBTL1ALDH1A1 | |
| SCHEMBL846120 | 0.75 | ALDH1A1 (0.48) | AOC3ADRA1AADRA2AL3MBTL1ALDH1A1 | |
| SCHEMBL21674419 | 0.74 | ADRA2A (0.46) | AOC3ADRA1AADRA2AL3MBTL1ALDH1A1 | |
| SCHEMBL21526725 | 0.73 | ALDH1A1 (0.46) | AOC3ADRA1AADRA2AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054877-A1 | NOVEL CYCLIC SULFONAMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041246-A1 | NOVEL CYCLIC SULFONAMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-08-19 | — | — | WO | disclosed |