Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 14/20 | 0.70 |
| ▸ | METAP1 | P53582 | 8/20 | 0.70 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | MC3R | P41968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7360631 | 0.99 | METAP2 (0.69) | METAP2METAP1CPB2CTSLHTT | |
| SCHEMBL7358236 | 0.82 | METAP2 (1.00) | METAP2METAP1 | |
| SCHEMBL7356692 | 0.82 | METAP2 (1.00) | METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7360347 | 0.81 | METAP2 (0.98) | METAP2METAP1 | |
| SCHEMBL7362323 | 0.81 | METAP2 (0.60) | METAP2METAP1 | |
| SCHEMBL6487669 | 0.79 | METAP2 (0.78) | METAP2METAP1 | |
| SCHEMBL6487738 | 0.78 | METAP2 (0.69) | METAP2METAP1CTSL | |
| SCHEMBL7358549 | 0.77 | METAP2 (0.54) | METAP2METAP1CTSLMC4RMC3R | |
| SCHEMBL7354326 | 0.77 | METAP2 (0.61) | METAP2METAP1MC4RMC3R | |
| Hydrochloric Acid SCHEMBL7353863 | 0.76 | METAP2 (0.53) | METAP2METAP1CTSLMC4RMC3R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | claimed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |
| WO-1999052879-A1 | ACYLRESORCINOL DERIVATIVES AS SELECTIVE VITRONECTIN RECEPTOR INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-21 | — | — | WO | disclosed |