Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 19/20 | 0.46 |
| ▸ | ITGAV | P06756 | 17/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.41 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980556 | 0.90 | ITGB3 (0.42) | ITGB3ITGAVITGA2BITGB1ITGA5 | |
| SCHEMBL7980549 | 0.89 | ITGB3 (0.43) | ITGB3ITGAVITGA2BITGB1ITGA5 | |
| SCHEMBL7357208 | 0.85 | ITGB3 (0.64) | ITGB3ITGAVITGA2BITGB1ITGA5 | |
| SCHEMBL7982799 | 0.84 | ITGB3 (0.48) | ITGB3ITGAVITGA2BEGLN2EGLN1 | |
| SCHEMBL7982298 | 0.84 | ITGB3 (0.62) | ITGB3ITGAVITGA2BITGB1ITGA5 | |
| SCHEMBL7346960 | 0.83 | ITGB3 (0.50) | ITGB3ITGAVITGA2B | |
| SCHEMBL7979117 | 0.83 | ITGB3 (0.64) | ITGB3ITGAVITGA2B | |
| SCHEMBL7969254 | 0.79 | ITGB3 (0.46) | ITGB3ITGAVITGA2BITGB1ITGA5 | |
| SCHEMBL5253002 | 0.77 | ITGB3 (0.74) | ITGB3ITGAVITGA2B | |
| SCHEMBL7969121 | 0.75 | ITGB3 (0.44) | ITGB3ITGAVITGA2BEGLN2EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214834-B1 | ANGIOGENESIS INHIBITORS; ANTIINFLAMMATORY AGENTS; ANTICANCER AGENTS | DUPONT PHARMACEUTICALS COMPANY | 2001-04-10 | — | — | US | claimed |
| WO-1998043962-A1 | HETEROCYCLIC INTEGRIN INHIBITOR PRODRUGS | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-10-08 | — | — | WO | claimed |
| US-6214834-B1 | ANGIOGENESIS INHIBITORS; ANTIINFLAMMATORY AGENTS; ANTICANCER AGENTS | DUPONT PHARMACEUTICALS COMPANY | 2001-04-10 | — | — | US | disclosed |
| WO-1998043962-A1 | HETEROCYCLIC INTEGRIN INHIBITOR PRODRUGS | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-10-08 | — | — | WO | disclosed |