Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 13/20 | 0.52 |
| ▸ | MMP13 | P45452 | 12/20 | 0.52 |
| ▸ | MMP1 | P03956 | 8/20 | 0.51 |
| ▸ | MMP3 | P08254 | 8/20 | 0.51 |
| ▸ | MMP9 | P14780 | 8/20 | 0.50 |
| ▸ | MMP8 | P22894 | 6/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.49 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.48 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.48 |
| ▸ | MMP7 | P09237 | 4/20 | 0.47 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13639192 | 0.90 | MMP2 (0.50) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL13639249 | 0.90 | MMP2 (0.50) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL5639380 | 0.88 | MMP2 (0.57) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL1499947 | 0.88 | MMP2 (0.50) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL13639190 | 0.88 | MMP2 (0.48) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL13639186 | 0.88 | MMP2 (0.48) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL7347538 | 0.88 | L3MBTL1 (0.55) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL7347534 | 0.88 | L3MBTL1 (0.55) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL7348211 | 0.88 | L3MBTL1 (0.55) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL29541878 | 0.86 | SLC1A3 (0.48) | MMP2MMP13MMP1MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1197849-C | 2,3,4,5-tetrahydro-1H-[1,4] benzodiazepine-3-hydroxamic acid as matrix metalloproteinase inhibitors | AMERICAN CYANAMID CO (US) | 2005-04-20 | — | — | CN | disclosed |
| CN-1337952-A | 2,3,4, 5-tetrahydro-1H- [1,4] benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors | AMERICAN CYANAMID CO (US) | 2002-02-27 | — | — | CN | disclosed |
| EP-1147095-A1 | 2, 3, 4, 5-TETRAHYDRO-1H-[1, 4] BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| CN-1293663-A | 2,3,4,5-tetrahydro-1H-[1,4] benzodiazepine-3-hydroxamix acids as matrix metal-protease | AMERICAN CYANAMID CO (US) | 2001-05-02 | — | — | CN | disclosed |
| EP-1051407-A1 | 2,3,4,5-TETRAHYDRO-1H-[1,4]-BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-2000044730-A1 | 2,3,4,5-TETRAHYDRO-1H-[1,4]BENZODIAZEPINE-3-HYDROXAMIC ACID AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |
| US-6071903-A | ENZYME INHIBITORS OF MATRIX METALLOPROTEINASES (MMPS); ANTITUMOR,-CARCINOGENIC AND -ARTHRITIC AGENTS; OSTEOARTHRITIS; RHEUMATOID DISEASES; DEGENERATIVE CARTILAGE LOSS; LONG-ACTING, ORALLY BIOAVAILABLE NONPEPTIDE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-06-06 | — | — | US | disclosed |
| WO-1999037625-A1 | 2,3,4,5-TETRAHYDRO-1H-[1,4]-BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1999-07-29 | — | — | WO | disclosed |