Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 8/20 | 0.44 |
| ▸ | METAP1 | P53582 | 6/20 | 0.44 |
| ▸ | REN | P00797 | 2/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.36 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10353206 | 1.00 | METAP2 (0.44) | METAP2METAP1RENSLC1A3SLC1A2 | |
| SCHEMBL7284894 | 0.82 | REN (0.43) | METAP2METAP1REN | |
| SCHEMBL7284964 | 0.82 | REN (0.43) | METAP2METAP1REN | |
| SCHEMBL7284898 | 0.82 | REN (0.43) | METAP2METAP1REN | |
| SCHEMBL7284908 | 0.82 | REN (0.43) | METAP2METAP1REN | |
| SCHEMBL5671311 | 0.81 | REN (0.40) | METAP2METAP1REN | |
| Hydrochloric Acid SCHEMBL7285775 | 0.81 | REN (0.43) | METAP2METAP1REN | |
| Hydrochloric Acid SCHEMBL7285779 | 0.81 | REN (0.43) | METAP2METAP1REN | |
| Hydrochloric Acid SCHEMBL7351019 | 0.81 | REN (0.43) | METAP2METAP1REN | |
| Hydrochloric Acid SCHEMBL7285772 | 0.81 | REN (0.43) | METAP2METAP1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0389535-A1 | RENIN INHIBITORS, PROCESSES FOR PREPARING THEM, METHODS FOR USING THEM, AND COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY (US) | 1990-10-03 | — | — | EP | disclosed |
| WO-1989007610-A1 | RENIN INHIBITORS CONTAINING alpha-HETEROATOM AMINO ACIDS | WARNER-LAMBERT COMPANY (US) | 1989-08-24 | — | — | WO | disclosed |
| WO-1989003841-A1 | RENIN INHIBITORS, PROCESSES FOR PREPARING THEM, METHODS FOR USING THEM, AND COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY (US) | 1989-05-05 | — | — | WO | disclosed |
| WO-1989003820-A1 | BRANCHED BACKBONE RENIN INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-05-05 | — | — | WO | disclosed |