Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.43 |
| ▸ | METAP2 | P50579 | 12/20 | 0.43 |
| ▸ | METAP1 | P53582 | 8/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284898 | 1.00 | REN (0.43) | RENMETAP2METAP1CPB2HSD17B1 | |
| SCHEMBL7284908 | 1.00 | REN (0.43) | RENMETAP2METAP1CPB2HSD17B1 | |
| SCHEMBL7284894 | 1.00 | REN (0.43) | RENMETAP2METAP1CPB2HSD17B1 | |
| Hydrochloric Acid SCHEMBL7285772 | 0.99 | REN (0.43) | RENMETAP2METAP1CPB2HSD17B1 | |
| Hydrochloric Acid SCHEMBL7285775 | 0.99 | REN (0.43) | RENMETAP2METAP1CPB2HSD17B1 | |
| Hydrochloric Acid SCHEMBL7285779 | 0.99 | REN (0.43) | RENMETAP2METAP1CPB2HSD17B1 | |
| Hydrochloric Acid SCHEMBL7351019 | 0.99 | REN (0.43) | RENMETAP2METAP1CPB2HSD17B1 | |
| SCHEMBL7326847 | 0.84 | REN (0.46) | RENMETAP2METAP1CPB2 | |
| SCHEMBL10353206 | 0.82 | METAP2 (0.44) | RENMETAP2METAP1 | |
| SCHEMBL7358079 | 0.82 | METAP2 (0.44) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297815-B1 | Fluorine containing renin inhibitors | PFIZER (US) | 1994-07-27 | — | — | EP | disclosed |
| US-4855303-A | Fluorine containing renin inhibitors | PFIZER INC. (US) | 1989-08-08 | — | — | US | disclosed |
| EP-0297815-A2 | Fluorine containing renin inhibitors | PFIZER INC. (US) | 1989-01-04 | — | — | EP | disclosed |