Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 11/20 | 0.60 |
| ▸ | METAP1 | P53582 | 8/20 | 0.60 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.44 |
| ▸ | CTSD | P07339 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362423 | 0.85 | METAP2 (0.63) | METAP2METAP1F2RL1 | |
| Hydrochloric Acid SCHEMBL7352923 | 0.84 | METAP2 (0.62) | METAP2METAP1F2RL1 | |
| SCHEMBL7354275 | 0.83 | METAP2 (0.63) | METAP2METAP1 | |
| SCHEMBL7356908 | 0.81 | METAP2 (0.70) | METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7355712 | 0.80 | METAP2 (0.69) | METAP2METAP1 | |
| SCHEMBL7354468 | 0.80 | METAP2 (0.65) | METAP2METAP1EPHX1CTSD | |
| SCHEMBL7355283 | 0.80 | METAP2 (0.65) | METAP2METAP1CTSD | |
| Hydrochloric Acid SCHEMBL7350551 | 0.79 | METAP2 (0.64) | METAP2METAP1EPHX1CTSD | |
| SCHEMBL7351699 | 0.79 | METAP2 (0.66) | METAP2METAP1EPHX1F2RL1CTSD | |
| SCHEMBL7352517 | 0.78 | METAP2 (0.62) | METAP2METAP1EPHX1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | claimed |
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |