Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 12/20 | 0.42 |
| ▸ | MMP1 | P03956 | 12/20 | 0.42 |
| ▸ | MMP2 | P08253 | 9/20 | 0.40 |
| ▸ | MMP8 | P22894 | 8/20 | 0.39 |
| ▸ | MMP9 | P14780 | 7/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358396 | 0.82 | MMP3 (0.43) | MMP3MMP1MMP2MMP8MMP9 | |
| SCHEMBL7399055 | 0.78 | MMP3 (0.44) | MMP3MMP1MMP2MMP8MMP9 | |
| SCHEMBL8902722 | 0.77 | MMP3 (0.46) | MMP3MMP1MMP2MMP8MMP9 | |
| SCHEMBL7562073 | 0.77 | MMP3 (0.44) | MMP3MMP1MMP2MMP8MMP9 | |
| SCHEMBL7481678 | 0.75 | MMP3 (0.42) | MMP3MMP1MMP2MMP8MMP9 | |
| SCHEMBL7359109 | 0.72 | CASP3 (0.39) | MMP3MMP1MMP2MMP8MMP9 | |
| SCHEMBL7475200 | 0.72 | MMP3 (0.47) | MMP3MMP1MMP2MMP8MMP9 | |
| SCHEMBL6957808 | 0.69 | MMP3 (0.55) | MMP3MMP1MMP2MMP8MMP9 | |
| SCHEMBL6957803 | 0.69 | MMP3 (0.55) | MMP3MMP1MMP2MMP8MMP9 | |
| SCHEMBL7479205 | 0.69 | MMP3 (0.43) | MMP3MMP1MMP2MMP8MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998025949-A1 | SUBSTITUTED 5-AMINO-1,3,4-THIADIAZOLE-2-THIONES | PROSCRIPT, INC. (US) | 1998-06-18 | — | — | WO | disclosed |
| EP-0845002-A2 | AMINO ACID AMIDES OF 5-AMINO-1,3,4-THIADIAZONES AND THEIR USE AS INHIBITORS FOR MATRIX METALLOPROTEINASES | PROSCRIPT, INC. (US) | 1998-06-03 | — | — | EP | disclosed |
| US-5677282-A | ENZYME INHIBITOR; OSTEOARTHRITIS AND RHEUMATIC DISORDERS | PROSCRIPT, INC. (US) | 1997-10-14 | — | — | US | disclosed |
| WO-1996040745-A2 | AMINO ACID AMIDES OF 5-AMINO-1,3,4-THIADIAZONES AND THEIR USE AS INHIBITORS FOR MATRIX METALLOPROTEINASES | PROSCRIPT, INC. (US) | 1996-12-19 | — | — | WO | disclosed |