Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4940044 | 0.98 | KDM4E (0.51) | KDM4EKMT2ASMN1; SMN2FOXM1RAB9A | |
| SCHEMBL736957 | 0.97 | KDM4E (0.50) | KDM4EKMT2ASMN1; SMN2FOXM1RAB9A | |
| SCHEMBL737638 | 0.96 | RAB9A (0.46) | KDM4EKMT2ASMN1; SMN2FOXM1RAB9A | |
| SCHEMBL737726 | 0.79 | MAPT (0.48) | KDM4EKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL737545 | 0.77 | MAPT (0.50) | KDM4EKMT2ARAB9AHRH3MAPT | |
| SCHEMBL736647 | 0.75 | HRH3 (0.41) | KDM4EKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL7902701 | 0.75 | FOXM1 (0.53) | KDM4EKMT2ASMN1; SMN2FOXM1HRH3 | |
| SCHEMBL737728 | 0.74 | HRH3 (0.41) | KDM4EKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL16046663 | 0.74 | LTA4H (0.62) | KDM4EKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL737369 | 0.74 | HRH3 (0.42) | KDM4EKMT2ASMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138206-B2 | Piperidine derivative | MSD. K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| US-20090137576-A1 | Novel Piperidine Derivative | MSD K.K. (JP) | 2009-05-28 | — | — | US | disclosed |
| CN-101228127-A | Novel Piperidine Derivatives | BANYU PHARMA CO LTD (JP) | 2008-07-23 | — | — | CN | disclosed |
| EP-1892241-A1 | NOVEL PIPERIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-02-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137576-A1 | Novel Piperidine Derivative | HRH4, HRH3, HRH1 | KDM4E 1039/4885KMT2A 825/4885SMN1; SMN2 4135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.