Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 5/20 | 0.69 |
| ▸ | CTSL | P07711 | 3/20 | 0.69 |
| ▸ | CTSS | P25774 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | ECE1 | P42892 | 3/20 | 0.62 |
| ▸ | MME | P08473 | 2/20 | 0.62 |
| ▸ | CASP3 | P42574 | 3/20 | 0.60 |
| ▸ | CTSK | P43235 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP4 | P49662 | 1/20 | 0.54 |
| ▸ | CASP5 | P51878 | 1/20 | 0.54 |
| ▸ | CASP9 | P55211 | 1/20 | 0.54 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359269 | 1.00 | CTSB (0.69) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL7049933 | 0.95 | CTSB (0.72) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL29861103 | 0.93 | CTSB (0.69) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL6272667 | 0.91 | ECE1 (0.64) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL7378851 | 0.91 | ECE1 (0.64) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL24734375 | 0.90 | CTSL (0.71) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL5145628 | 0.90 | CTSL (0.71) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL7264750 | 0.90 | CTSL (0.71) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL8837339 | 0.90 | CTSL (0.71) | CTSBCTSLCTSSMEN1KMT2A | |
| SCHEMBL8837344 | 0.90 | CTSL (0.71) | CTSBCTSLCTSSMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998025949-A1 | SUBSTITUTED 5-AMINO-1,3,4-THIADIAZOLE-2-THIONES | PROSCRIPT, INC. (US) | 1998-06-18 | — | — | WO | disclosed |
| EP-0845002-A2 | AMINO ACID AMIDES OF 5-AMINO-1,3,4-THIADIAZONES AND THEIR USE AS INHIBITORS FOR MATRIX METALLOPROTEINASES | PROSCRIPT, INC. (US) | 1998-06-03 | — | — | EP | disclosed |
| US-5677282-A | ENZYME INHIBITOR; OSTEOARTHRITIS AND RHEUMATIC DISORDERS | PROSCRIPT, INC. (US) | 1997-10-14 | — | — | US | disclosed |
| WO-1996040745-A2 | AMINO ACID AMIDES OF 5-AMINO-1,3,4-THIADIAZONES AND THEIR USE AS INHIBITORS FOR MATRIX METALLOPROTEINASES | PROSCRIPT, INC. (US) | 1996-12-19 | — | — | WO | disclosed |