Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GPR183 | P32249 | 3/20 | 0.43 |
| ▸ | YAP1 | P46937 | 1/20 | 0.43 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ITGAL | P20701 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4812606 | 1.00 | USP2 (0.67) | USP2NOTUMNPC1RAB9ATDP1 | |
| SCHEMBL14262511 | 0.84 | FAAH (0.59) | USP2TDP1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14262199 | 0.82 | L3MBTL1 (0.58) | USP2MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL4815957 | 0.81 | USP2 (0.78) | USP2MEN1KMT2AGPR183YAP1 | |
| SCHEMBL7356750 | 0.81 | USP2 (0.78) | USP2MEN1KMT2AGPR183YAP1 | |
| SCHEMBL5324731 | 0.80 | NPC1 (0.66) | NPC1RAB9ATDP1GPR183SMN1; SMN2 | |
| SCHEMBL5324726 | 0.80 | NPC1 (0.66) | NPC1RAB9ATDP1GPR183SMN1; SMN2 | |
| SCHEMBL14262502 | 0.79 | RAB9A (0.59) | USP2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL14262512 | 0.79 | RAB9A (0.56) | USP2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL21800713 | 0.71 | EPHX2 (0.55) | USP2NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109787-A1 | ARYLPIPERAZINES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS (MMP) | AstraZeneca AB (SE) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012478-A1 | ARYLPIPERAZINES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS (MMP) | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |