Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 3/20 | 0.46 |
| ▸ | FAAH | O00519 | 3/20 | 0.44 |
| ▸ | LIPE | Q05469 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368341 | 0.82 | MGLL (0.55) | MGLLKCNH2HRH3L3MBTL1CCR3 | |
| SCHEMBL7359608 | 0.76 | F2 (0.68) | MGLLCCR3 | |
| SCHEMBL7365807 | 0.76 | CCR3 (0.45) | MGLLKCNH2CYP2C9CYP2C19MAPK14 | |
| SCHEMBL7233081 | 0.72 | HTT (0.65) | MGLLCYP2C9CYP2C19HTR2BMAPK14 | |
| SCHEMBL7370469 | 0.71 | TP53 (0.59) | MGLLCCR3 | |
| SCHEMBL6397917 | 0.71 | MGLL (0.66) | MGLLCCR3FAAH | |
| SCHEMBL7360128 | 0.71 | F2 (0.69) | MGLLCCR3 | |
| SCHEMBL7362951 | 0.70 | F2 (0.60) | MGLLKCNH2HRH3 | |
| SCHEMBL1172481 | 0.70 | FAAH (0.77) | MGLLCCR3FAAH | |
| SCHEMBL12466612 | 0.70 | HRH3 (0.57) | MGLLKCNH2HRH3L3MBTL1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960102-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | Du Pont Pharmaceuticals Company (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998001428-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-01-15 | — | — | WO | disclosed |