Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359688 | 0.77 | NOS1 (0.48) | NOS1 | |
| SCHEMBL19235750 | 0.69 | — | — | |
| SCHEMBL3454166 | 0.68 | PNP (0.32) | NOS1 | |
| SCHEMBL2273420 | 0.67 | — | — | |
| SCHEMBL16554109 | 0.67 | — | — | |
| SCHEMBL584983 | 0.64 | NOS1 (0.36) | NOS1 | |
| Hydrochloric Acid SCHEMBL16741182 | 0.63 | KDM4E (0.36) | NOS1 | |
| SCHEMBL2044798 | 0.61 | NOS1 (0.49) | NOS1 | |
| SCHEMBL18520768 | 0.60 | NOS1 (0.46) | NOS1 | |
| Hydrochloric Acid SCHEMBL28835504 | 0.60 | KDM4E (0.33) | NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401844-A | Chemical intermediates for treatment of parkinson*s disease | SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) | 1995-03-28 | — | — | US | disclosed |
| US-5196533-A | Treatment of Parkinson*s disease, inhibitor of thymidylate synthetase | SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION, USA (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0138995-B1 | REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES | South Alabama Medical Science Foundation (US) | 1991-08-14 | — | — | EP | disclosed |
| EP-0138995-A4 | REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES. | UNIV SOUTH ALABAMA (US) | 1988-05-10 | — | — | EP | disclosed |
| EP-0138995-A1 | REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES. | UNIV SOUTH ALABAMA (US) | 1985-05-02 | — | — | EP | disclosed |
| WO-1984004040-A1 | REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES | UNIV SOUTH ALABAMA (US) | 1984-10-25 | — | — | WO | disclosed |