Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | METAP2 | P50579 | 5/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 4/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 4/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330273 | 0.77 | REN (0.36) | RENMETAP2CTSDMETAP1BACE1 | |
| SCHEMBL7325941 | 0.73 | BACE1 (0.44) | RENMETAP2CTSDMETAP1BACE1 | |
| SCHEMBL9831134 | 0.71 | REN (0.51) | RENMETAP2CPB2MMP2MMP8 | |
| SCHEMBL10608625 | 0.71 | REN (0.51) | RENMETAP2CPB2MMP2MMP8 | |
| SCHEMBL14415380 | 0.71 | REN (0.60) | RENMETAP2CPB2MMP2MMP8 | |
| SCHEMBL7355979 | 0.71 | REN (0.48) | RENMETAP2CPB2MMP2MMP8 | |
| SCHEMBL14420289 | 0.71 | REN (0.60) | RENMETAP2CPB2MMP2MMP8 | |
| Hydrochloric Acid SCHEMBL9832396 | 0.70 | REN (0.50) | RENMETAP2CPB2MMP2MMP8 | |
| Hydrochloric Acid SCHEMBL9832917 | 0.70 | REN (0.47) | RENMETAP2CPB2MMP2MMP8 | |
| Hydrochloric Acid SCHEMBL7385221 | 0.70 | REN (0.47) | RENMETAP2CPB2MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415981-A4 | RETROVIRAL PROTEASE INHIBITORS | — | 1991-10-09 | — | — | EP | disclosed |
| EP-0415981-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0342541-A2 | Retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1989-11-23 | — | — | EP | disclosed |
| WO-1989010752-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |