Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 0.38 |
| ▸ | MMP8 | P22894 | 7/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 8/20 | 0.37 |
| ▸ | MMP3 | P08254 | 7/20 | 0.37 |
| ▸ | MMP9 | P14780 | 6/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 2/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.36 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.36 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.36 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.36 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.36 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.36 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.36 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363203 | 0.86 | MMP1 (0.40) | MMP1MMP8MMP2MMP3MMP9 | |
| SCHEMBL7360065 | 0.86 | MMP1 (0.51) | MMP1MMP8MMP2MMP3MMP9 | |
| SCHEMBL6416552 | 0.84 | MMP1 (0.54) | MMP1MMP8MMP2MMP3MMP9 | |
| SCHEMBL6416222 | 0.84 | MMP1 (0.39) | MMP1MMP8MMP2MMP3MMP9 | |
| SCHEMBL7354511 | 0.82 | MMP1 (0.44) | MMP1MMP8MMP2MMP3MMP9 | |
| SCHEMBL7356588 | 0.82 | MMP1 (0.41) | MMP1MMP8MMP2MMP3MMP9 | |
| SCHEMBL7364166 | 0.80 | MMP9 (0.41) | MMP1MMP8MMP2MMP3MMP9 | |
| SCHEMBL7356834 | 0.80 | MMP1 (0.41) | MMP1MMP8MMP2MMP3MMP9 | |
| SCHEMBL7363512 | 0.78 | MMP3 (0.45) | MMP1MMP8MMP2MMP3PSMB11 | |
| SCHEMBL7357715 | 0.77 | NPC1 (0.49) | MMP1MMP8MMP9PSMB11PSMA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0667770-B1 | INHIBITION OF TNF PRODUCTION | BRITISH BIOTECH PHARM (GB) | 1997-03-19 | — | — | EP | disclosed |
| EP-0667770-A1 | INHIBITION OF TNF PRODUCTION. | BRITISH BIOTECH PHARM (GB) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994010990-A1 | INHIBITION OF TNF PRODUCTION | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1994-05-26 | — | — | WO | disclosed |